@article{Gonçalves Rodrigues_de Senna Pereira_Mena Barreto de Freitas_Ubessi_Bosio Tedesco_2021, title={Antiproliferative analysis of aqueous extracts of cabreúva (Myrocarpus frondosus) on the Allium cepa cell cycle}, volume={73}, url={https://riviste.fupress.net/index.php/caryologia/article/view/776}, DOI={10.13128/caryologia-776}, abstractNote={<p class="p1"><span class="s1">Myrocarpus frondosus</span> is widely used in Brazilian folk medicine for bronchitis, gastritis, ulcers and wound asepsis. However, there is a scarcity of scientific data proving the safe use of tea of this species or if there is any toxic effect on the human organism. This study aimed to evaluate the antiproliferative effect of aqueous extracts of cabreúva on the <span class="s1">Allium cepa</span> cell cycle. The aqueous extracts were prepared from leaves, bark and roots (dried material) of the species in two concentrations: 2.5 and 5.0 grams in 250 mL of distilled water. The aqueous extract of the leaves was obtained by infusion and the aqueous extract of the bark and roots by decoction. Distilled water was used as negative control and glyphosate 2% as positive control. Eight groups of four onion bulbs were evaluated and each group corresponded to one treatment and, in each group, 4000 cells were analyzed and the mitotic index was calculated. The results demonstrated reduction of mitotic indices in all treatments when compared to the negative control in water. The aqueous extracts of cabreúva in the studied concentrations have antiproliferative action on the <span class="s1">Allium cepa</span> cell cycle, ensuring the safe use of tea of this medicinal species.</p>}, number={4}, journal={Caryologia}, author={Gonçalves Rodrigues, Luísa and de Senna Pereira, Julia and Mena Barreto de Freitas, Jéssica and Ubessi, Cassiane and Bosio Tedesco, Solange}, year={2021}, month={May}, pages={39–44} }