Influence of chronic alcoholic intoxication and lighting regime on karyometric and ploidometric parameters of hepatocytes of rats

Authors

  • Yuri A. Kirillov Federal State Budgetary Scientific Institution «Research Institute of Human Morphology»
  • Maria A. Kozlova Federal State Budgetary Scientific Institution «Research Institute of Human Morphology»
  • Lyudmila A. Makartseva Federal State Budgetary Scientific Institution «Research Institute of Human Morphology»
  • Igor A. Chernov FSBEI HE Tyumen State Medical University of the Ministry of Health of Russia
  • Evgeniya V. Shtemplevskaya Federal State Budgetary Scientific Institution «Research Institute of Human Morphology»
  • David A. Areshidze Federal State Budgetary Scientific Institution «Research Institute of Human Morphology»

DOI:

https://doi.org/10.36253/caryologia-1122

Keywords:

caryometry, ploidy, hepatocyte, circadian, morphometry

Abstract

The features of the diurnal dynamics of the area of rat hepatocyte nuclei and their ploidy were studied under conditions of a standart (fixed) light regime and constant illumination, as well as under chronic exposure to alcohol in the mentioned light regimes. It has been shown that exposure to alcohol and exposure to constant illumination separately lead to a change in the amplitude-phase characteristics of the circadian rhythm of the nucleus area, while the combined effect of these factors leads to a complete destruction of the rhythm, which indicates a violation of adaptation processes. An increase in the average ploidy of hepatocyte nuclei in chronic alcohol intoxication is also shown, while in animals kept under constant illumination without drinking alcohol, the values of this parameter decrease, which indicates a successful course of the adaptation process. The conducted research indicates that the results of karyometric and ploidometric analysis characterize the degree of influence of alcohol intoxication and changes in the light regime on the liver of rats, reflecting the rate of efficiency of adaptation to these factors.

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Published

2021-12-21

How to Cite

Kirillov, Y. A., Kozlova, M. A., Makartseva, L. A., Chernov, I. A., Shtemplevskaya, E. V., & Areshidze, D. A. (2021). Influence of chronic alcoholic intoxication and lighting regime on karyometric and ploidometric parameters of hepatocytes of rats. Caryologia, 74(3), 45-51. https://doi.org/10.36253/caryologia-1122

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Articles