Assessment of anti-cytotoxic, anti-genotoxic and antioxidant potentials of Bulgarian Rosa alba L. essential oil
DOI:
https://doi.org/10.13128/caryologia-260Keywords:
Rosa alba L. essential oil, rose oil components, genotoxicity, anti-cytotoxicity, anti-genotoxicity, antioxidant effectAbstract
Bulgarian Rosa alba L. essential oil is widely used in perfumery, cosmetics and pharmacy. The scarce data about its cytotoxic/genotoxic effect and anti-cytotoxic/anti-genotoxic potential gave us a reason to set our aim: i) to study its cytotoxic/genotoxic activities, iii) to explore its cytoprotective/genoprotective potential against the experimental mutagen N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) in two experimental test-systems - barley and human lymphocytes using appropriate endpoints and iii) to assess its antioxidant properties. Findings about chemical composition of rose essential oil would help us to explain its activities. Chromatogaphic profile of rose essential oil was obtained by Gas Chromatography-Mass Spectrometry and quantificaton of particular constituents was done with a Gas Chromatography-FID system. Superoxide anion radical scavenging, DPPH inhibition and iron ion chelating activity were used to study a possible antioxidant potential of the rose oil. Its defense potential was investigated by induction of chromosome aberrations and micronuclei in both test-systems. Cytogenetic analysis showed a low cytotoxic effect in both test-systems and no high genotoxic effect in human lymphocytes in vitro in a dose-dependent manner. Rose oil possessed a well-expressed anti-cytotoxic/anti-genotoxic potential against MNNG manifested by decreasing both of chromosome aberrations and micronuclei regardless of the experimental schemes used. A well-expressed concentration-depended free radical scavenging activity of the essential oil was obtained. Current data suggest a promising ethnopharmacological potential of Bulgarian white rose essential oil.
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References
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Drablos F, Feyzi E, Aas PA, Vaagbo CB, Kavli B, Bratlie MS, Pena-Diaz J, Otterlei M, Slupphaug G, Krokan HE. 2004. Alkylation damage in DNA and RNA repair mechanisms and medical significance. DNA Repair (Amst). 3: 1389-1407. doi: 10.1016/j.dnarep.2004.05.004
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Fukada M, Kano E, Miyoshi M, Komaki R, Watanabe T. 2011. Effect of “Rose Essential Oil” Inhalation on Stress-Induced Skin-Barrier Disruption in Rats and Humans. Chem. Senses. 37(4): 347-356. https://doi.org/10.1093/chemse/bjr108.
Gateva S, Jovtchev G, Stankov A, Gregan F. 2015. Salvia Extract Can Decrease DNA Damage Induced by Zeocin. Int. J. Pharm. Med. Biol. Sci. 4 (1): 1-10. doi: 10.12720/ijpmbs.4.1.1-10
Gateva S, Jovtchev G, Stankov A, Dobreva A, Mileva M. 2018. Geraniol inhibits the genotoxic effect of MNNG in plant and human lymphocyte test-systems. Compt. Rend Acad. Bulg. Sci. (in press).
Gokbulut I, Bilenler T, Karabulut I. 2013. Determination of Chemical Composition, Total Phenolic, Antimicrobial, and Antioxidant Activities of Echinophora tenuifolia Essential Oil. Int. J. Food Prop. 16 (7): 1442-1451.
Gordon MH. 1990. The mechanism of antioxidant action in vitro. B.J.F. Hudson, (ed.). Food antioxidants, Elsevier Applied Science: London: UK, 1–18.
Hagag HA, Bazaid SA, Abdel-Hameed El-SS, Salman M. 2014. Cytogenetic, cytotoxic and GC-MS studies on concrete and absolute oils from Taif rose, Saudi Arabia. Cytotechnology 66: 913–923. doi: 10.1007/s10616-013-9644-5.
Hajhashemi V, Ghannadi A, Sharif B. 2003. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J. Ethnopharmacol. 89: 67–71.
Hatano T, Edamatsu R, Mori A, Fujita Y, Yasuhara E, Okuda T. 1989. Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull. 37: 2016-2021.
Horváth G, Ács K. 2015. Essential oils in the treatment of respiratory tract diseases highlighting their role in bacterial infections and their anti-inflammatory action: a review. Flavour and Fragrance J. 30: 331–341. |https://doi.org/10.1002/ffj.3252.
Hsouna AB, Trigui M., Mansour RB, Jarraya RM, Damak M, Jaoua S. 2011. Chemical composition, cytotoxicity effect and antimicrobial activity of Ceratonia siliqua essential oil with preservative effects against Listeria inoculated in minced beef meat. Int. J. Food Microbiol. 148: 66–72. doi: 10.1016/j.ijfoodmicro.2011.04.028.
http://www.iso.org/ ISO 9842:2003. Oil of rose (Rosa x damascena Miller).
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2021-04-16
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Gateva, S., Jovtchev, G., Chanev, C., Georgieva, A., Stankov, A., Dobreva, A., & Mileva, M. (2021). Assessment of anti-cytotoxic, anti-genotoxic and antioxidant potentials of Bulgarian Rosa alba L. essential oil. Caryologia, 73(3). https://doi.org/10.13128/caryologia-260
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