Antiproliferative analysis of aqueous extracts of cabreúva (Myrocarpus frondosus) on the Allium cepa cell cycle

Authors

  • Cassiane Ubessi Federal University of Santa Maria
  • Luísa Gonçalves Rodrigues Federal University of Santa Maria
  • Julia de Senna Pereira Federal University of Santa Maria
  • Jéssica Mena Barreto de Freitas Federal University of Santa Maria
  • Solange Bosio Tedesco Federal University of Santa Maria

DOI:

https://doi.org/10.13128/caryologia-776

Keywords:

Myrocarpus frondosus; medicinal plant; mitotic index

Abstract

Myrocarpus frondosus is widely used in Brazilian folk medicine for bronchitis, gastritis, ulcers and wound asepsis. However, there is a scarcity of scientific data proving the safe use of tea of this species or if there is any toxic effect on the human organism. This study aimed to evaluate the antiproliferative effect of aqueous extracts of cabreúva on the Allium cepa cell cycle. The aqueous extracts were prepared from leaves, bark and roots (dried material) of the species in two concentrations: 2.5 and 5.0 grams in 250 mL of distilled water. The aqueous extract of the leaves was obtained by infusion and the aqueous extract of the bark and roots by decoction. Distilled water was used as negative control and glyphosate 2% as positive control. Eight groups of four onion bulbs were evaluated and each group corresponded to one treatment and, in each group, 4000 cells were analyzed and the mitotic index was calculated. The results demonstrated reduction of mitotic indices in all treatments when compared to the negative control in water. The aqueous extracts of cabreúva in the studied concentrations have antiproliferative action on the Allium cepa cell cycle, ensuring the safe use of tea of this medicinal species.

References

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Published

2021-03-28

How to Cite

Ubessi, C., Luísa Gonçalves Rodrigues, Julia de Senna Pereira, Jéssica Mena Barreto de Freitas, & Solange Bosio Tedesco. (2021). Antiproliferative analysis of aqueous extracts of cabreúva (Myrocarpus frondosus) on the Allium cepa cell cycle. Caryologia. International Journal of Cytology, Cytosystematics and Cytogenetics. https://doi.org/10.13128/caryologia-776

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