With this Special Issue "Open Science" edited by Luigi Campanella, Substantia contributes to the celebrations of the 150^th anniversary of the periodic table.

Cover image: Confocal, tissue clearing, brainbow (labeling technique) micrograph (magnification 30x) from an individually labeled axons in an embryonic chick ciliary ganglion, by Dr. Ryo Egawa, Nagoya University, Graduate School of Medicine, Nagoya, Japan. Courtesy of Nikon Small World (7^th Place, 2017 Photomicrography Competition, https://www.nikonsmallworld.com).