A preliminary report on X-chromosome sequence variability within Iranian population. Reporting new potential SNPs/ sequence variants as a source of population genetic markers
DOI:
https://doi.org/10.13128/caryologia-551Keywords:
X-chromosome, SNPs, population, haplotypeAbstract
X-chromosome and its independent loci, recently has gained importance in genetic investigations that are concerned with diseases control-case studies, as well as in population genetic analyses and phylogenetic investigations. The present study was performed as a preliminary investigation on X-chromosome sequence variability as a source of genetic diversity within Iranian population and to investigate potential use of these sequences for differentiating the ethnic groups within the country. A limited random sample could be obtained from four different ethnic populations, which were sequenced for TEX-11 gene of the X-chromosome. At the beginning we used seven specific primers related to seven known SNPs within TEX-11 gene. Later on we searched for the other known as well as new potential SNPs or sequence variants in the studied samples. We could identify 87 potential SNPs or sequence variants. Genetic diversity analysis revealed the presence of five haplotype groups within the studied sequences. AMOVA revealed no significant genetic differentiation among sample driven from the ethnic populations. Moreover, Mantel test did not show significant association between geographical distance and genetic distance of these samples, indicating that gene flow occurred among these populations with no geographical obstacle. This is the first report on X-chromosome sequence diversity analysis in Iran.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Masoud Sheidai, Mehdi Heydari Horestani, Golnaz Atri Roozbahani, Naser Kalhor, Fahimeh Koohdar, Zahra Noormohammadi
This work is licensed under a Creative Commons Attribution 4.0 International License.
- Copyright on any open access article in a journal published byCaryologia is retained by the author(s).
- Authors grant Caryologia a license to publish the article and identify itself as the original publisher.
- Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
- The Creative Commons Attribution License 4.0 formalizes these and other terms and conditions of publishing articles.
- In accordance with our Open Data policy, the Creative Commons CC0 1.0 Public Domain Dedication waiver applies to all published data in Caryologia open access articles.