The role of oleuropein against nanocomposite toxicity in fruit fly: evidence for lifespan extension
DOI:
https://doi.org/10.13128/caryologia-226Keywords:
Drosophila melanogaster, lifespan, oleuropein, toxicity, zinc oxide/titanium dioxide nanoparticlesAbstract
The effect of zinc oxide/titanium dioxide nanocomposite the lifespan of the fruit fly Drosophila melanogaster and the protective role of oleuropein, a strong antioxidant, against the zinc oxide/titanium dioxide were investigated. Chemicals prepared in different concentrations (0.005, 0.1, 0.5, and 1 g/L for zinc oxide/titanium dioxide; 0.1 mmol/L for oleuropein) have been separately applied to female and male populations of D. melanogaster for the control and application groups. In both female and male populations, it has been observed that zinc oxide/titanium dioxide has decreased the lifespan and oleuropein has increased the lifespan according to the control group, depending on the concentration. These findings demonstrate the beneficial effect of oleuropein, suggested as a protective role in the prevention of zinc oxide/titanium dioxide induced developmental toxicity.
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References
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Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP. 2009. Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol. 4(12): 876-883.
Braydich-Stolle LK, Schaeublin NM, Murdock RC, Jiang J, Biswas P, Schlager JJ, Hussain SM. 2009. Crystal structure mediates mode of cell death in TiO2 nanotoxicity. J Nanopart Res. 11:1361-1374.
Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C, Visioli F, Distante A, De Caterina R. 2003. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 23(4):622-629.
Çak?r ?, Bozcuk AN. 2000. Longevity in some wild-type and hybrid strains of Drosophila melanogaster. Turkish J Biol. 24(2):321-329.
Çolak DA, Atici T, Uysal H. 2016. Role of oleuropein on Drosophila induced ZnOTiO2 nanocomposite. IJBiMeS. 1(2):12-15.
Hamdi HK, Castellon R. 2005. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun. 334(3):769-778.
Heng BC, Zhao X, Xiong S, Ng KW, Boey FY, Loo JS. 2010. Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress. Food Chem Toxicol. 48(6):1762-1766.
Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y, Iwahashi H, Yamamoto K, Murayama H, Nakano H, Nanashima N, Niki E, Yoshida Y. 2009. Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells. Chem Res Toxicol. 22(3):543-553.
Hu X, Cook S, Wang P, Hwang HM. 2009. In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles. Sci Total Environ. 407(8):3070-3072.
Kang SJ, Kim BM, Lee YJ, Chung HW. 2008. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen. 49(5):399-405.
Karahalil B. 2013. Nanotechnology in food industry and safety issue. GIDA/J Food. 38(1):39-46.
Landsiedel R, Kapp MD, Schulz M, Wiench K, Oesch F. 2009. Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers. Mutat Res. 681(2-3):241-258.
Le Tutour B, Guedon D. 1992. Antioxidative activities of Olea europaea leaves and related phenolic compounds. Phytochem. 31(4):1173-1178.
Manna C, Galletti P, Cucciolla V, Moltedo O, Leone A, Zappia V. 1997. The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells. J Nutr. 127(2):286-292.
Mocan T, Clichici S, Ago?ton-Coldea L, Mocan L, Simon S, Ilie IR, Biri? AR, Mure?an A. 2010. Implications of oxidative stress mechanisms in toxicity of nanoparticles. Acta Physiol Hung. 97(3):247-255.
Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science. 311(5761):622-627.
Petkovi? J, Zegura B, Stevanovi? M, Drnovšek N, Uskokovi? D, Novak S, Filipi? M. 2011. DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2 nanoparticles in human hepatoma HepG2 cells. Nanotoxicol. 5(3):341-353.
Reeves JF, Davies SJ, Dodd NJ, Jha AN. 2008. Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO(2)) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. Mutat Res. 640(1-2):113-122.
Sohal RS, Mockett RJ, Orr WC. 2002. Mechanisms of aging: an appraisal of the oxidative stress hypothesis 1, 2. Free Radic Biol Med. 33(5):575-586.
Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. 2009. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res. 69(22):8784-8789.
van Acker SA, van Balen GP, van den Berg DJ, Bast A, van der Vijgh WJ. 1998. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem Pharmacol. 56(8):935-943.
Wang JJ, Sanderson BJ, and Wang H. 2007. Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutat Res. 628(2):99-106.
Xu A, Chai Y, Nohmi T, Hei TK. 2009. Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells. Part Fibre Toxicol. 6:3.
Yang H, Liu C, Yang D, Zhang H, Xi Z. 2009. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol. 29(1):69-78.
Yeber MC, Rodríguez J, Freer J, Durán N, Mansilla HD. 2000. Photocatalytic degradation of cellulose bleaching effluent by supported TiO2 and ZnO. Chemosphere. 41(8):1193-1197.
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Published
2021-04-16
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Atici, T., & Altun Çolak, D. (2021). The role of oleuropein against nanocomposite toxicity in fruit fly: evidence for lifespan extension. Caryologia, 73(3). https://doi.org/10.13128/caryologia-226
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